Data Set Information:

数据集包括77种蛋白质/蛋白质修饰的表达水平，这些蛋白质修饰在皮质的核部分产生可检测的信号。共有38只对照小鼠和34只三体小鼠（唐氏综合征），共计72只小鼠。在实验中，每个样本/小鼠对每种蛋白质进行了15次测量。因此，对于对照小鼠，有38x15或570个测量值，对于三体小鼠，有34x15或510个测量值。该数据集包含每个蛋白质共1080个测量值。每个测量都可以被视为一个独立的样本/鼠标。

根据基因型、行为和治疗等特征描述了八类小鼠。根据基因型，小鼠可以是对照组或三体组。根据行为学，一些小鼠被刺激学习（情境休克），而另一些小鼠没有（情境休克），为了评估药物美金刚在三体小鼠恢复学习能力中的作用，一些小鼠被注射了药物，而另一些小鼠没有。

Classes:
c-CS-s：对照小鼠，刺激学习，注射生理盐水（9只小鼠）
c-CS-m：对照小鼠，刺激学习，注射美金刚（10只小鼠）
c-SC-s：对照小鼠，不受学习刺激，注射生理盐水（9只小鼠）
c-SC-m：对照小鼠，不受学习刺激，注射美金刚（10只小鼠）
t-CS-s：三体小鼠，刺激学习，注射生理盐水（7只小鼠）
t-CS-m：三体小鼠，刺激学习，注射美金刚（9只小鼠）
t-SC-s：三体小鼠，不受学习刺激，注射生理盐水（9只小鼠）
t-SC-m：三体小鼠，不受学习刺激，注射美金刚（9只小鼠）
其目的是确定在不同类别之间具有区别性的蛋白质子集。

Attribute Information:

1 Mouse ID
2..78 Values of expression levels of 77 proteins; the names of proteins are followed by a€?_na€?  indicating that they were measured in the nuclear fraction. For example: DYRK1A_n
79 Genotype: control (c) or trisomy (t)
80 Treatment type: memantine (m) or saline (s)
81 Behavior: context-shock (CS) or shock-context (SC)
82 Class: c-CS-s, c-CS-m, c-SC-s, c-SC-m,  t-CS-s, t-CS-m, t-SC-s, t-SC-m

Relevant Papers:

The posted data were analyzed by:
Higuera C, Gardiner KJ, Cios KJ (2015) Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS ONE 10(6): e0129126. [Web link] journal.pone.0129126

The data are a subset of the data analyzed by:
Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa ACS, Stasko M, et al. (2015) Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome. PLoS ONE 10(3): e0119491. [Web link]

Citation Request:

Higuera C, Gardiner KJ, Cios KJ (2015) Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS ONE 10(6): e0129126. [Web link] journal.pone.0129126

Clara Higuera Department of Software Engineering and Artificial Intelligence, Faculty of Informatics and the Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University Complutense, Madrid, Spain.
Email: clarahiguera '@' ucm.es

Katheleen J. Gardiner, creator and owner of the protein expression data, is currently with the Linda Crnic Institute for Down Syndrome, Department of Pediatrics, Department of Biochemistry and Molecular Genetics, Human Medical Genetics and Genomics, and Neuroscience Programs, University of Colorado, School of Medicine, Aurora, Colorado, USA.
Email: katheleen.gardiner '@' ucdenver.edu

Krzysztof J. Cios is currently with the Department of Computer Science, Virginia Commonwealth University, Richmond, Virginia, USA, and IITiS Polish Academy of Sciences, Poland.
Email: kcios '@' vcu.edu